A California native, Anthony excelled in football, basketball and baseball at Chaffey High School. He received a football scholarship to the University of Southern California, where he led the Trojans to the 1978 National Championship. Throughout his career at USC, he earned All-American and All-Conference awards.

Despite his skill and brilliant performance, Muñoz battled multiple injuries, including three knee surgeries that almost ended his career. His faith, family and sheer will helped him overcome the setbacks. His diligent workout routine and commitment to fitness paved the way for a remarkable professional career in which he missed just three games in his first 11 years in the NFL.

Anthony was selected by the Bengals as the third overall pick in the 1980 NFL Draft, and instantly became one of the league's premier lineman. He led the team to two Super Bowls, three AFC Central Division titles and two AFC Championships (1981 and 1988). Muñoz was named the NFL Offensive Lineman of the Year in 1981, 1987, and 1988 and the NFL Players Association Lineman of the Year in 1981, 1985, 1988, and 1989. From 1980 to 1990, he started in 185 of 186 games, was selected to play in eleven consecutive Pro Bowl games (1981-1991). Anthony is also a member of the NFL 75th Anniversary All-Time Team.

In April 2002, Anthony established the Anthony Muñoz Foundation, a non-profit organization that empowers children to reach their highest potential. Since its inception, the foundation has impacted thousands of children and raised more than $1,000,000 for foundation programs and select charities.

For his tireless community involvement, Anthony has received a number of prestigious awards. He was the recipient of the Athletes in Action Bart Starr Award for Leadership in 1990, and was named the Cincinnati Bengals Man of the Year for five consecutive years. In 1991, he was honored as the NFL Man of the Year, and in 2005, he received the Walter Camp Football Foundation's Man of the Year award.

Following his retirement, Muñoz received the ultimate honor for an athlete. He was elected into the Pro Football Hall of Fame in his first attempt on the ballot. In August of 1998, Muñoz was enshrined into the Hall of Fame in Canton, Ohio. He selected his son, Michael, to introduce him at the induction ceremonies. Anthony has been involved in several ventures since his playing days ended. He served as a television analyst for ESPN and Fox, and continues to cover the Cincinnati Bengals on WKRC-TV and WLW Radio. Anthony also serves on the NFL Youth Board.